Formulation And Evaluation Of Carboplatin Nanoparticles By Ionic Gelation Method

Abstract

A new development namely, controlled drug release dosage forms, has involved from the need for a prolonged drug effect, a better control of drug administration and the reduction of side effects. The controlled release delivery systems are those which deliver the drug in controlled manner over a specific period of time, so as to maintain plasma drug concentration within the therapeutic range. Carboplatin, a derivative of cisplatin, has far less nonhematologic toxicity, although myelosuppression may be slightly greater than that observed with cisplatin. Chitosan is a modified natural carbohydrate polymer prepared by the partial N- biopolymer derived from crustacean shells such as crabs, shrimps and lobsters. The Intranasal route is considered for drugs that are ineffective orally are used chronically require small doses and where rapid entry into the circulation is desired. In Ionic gelation method the chitosan nanoparticle was prepared by using sodium triphosphate as the cross-linking agent. From the result of present experimental investigation, it may be concluded that formulation F4 containing drug with polymer ratio was showing small vesicle size with desired release of Carboplatin. Hence F4 formulation was the optimized formulation. The optimize formulation was found to follow zero order pattern.