Formulation And Characterization of Nicardipine Hydrochloride Solid Dispersion by Using Solvent Evaporation Approach

Abstract

Nicardipine Hydrochloride is a calcium Channel blocker possessing antihypertensive & antianginal capabilities that's also frequently employed in the handling of both hypertension & angina (chest pain). Due to its poor aqueous solubility, it falls towards BCS class II and has low oral bioavailability (26%). The original study objective was to enhance Nicardipine Hydrochloride's water solubility using the Solvent Evaporation Approach. One of the most serious issues with this medication is its poor solubility in biological fluids, resulting in poor oral bioavailability. To boost its water solubility, solid dispersions (SDs) of nicardipine hydrochloride were produced employing PEG6000, Mannitol Chitosan extremely viscous, and Poloxamer 188. Nicardipine Hydrochloride SDs was produced in drug-to-polymer ratios of 1:1:2, 1:1:1, and 1:1:0 (w/w). The in-vitro release characteristics of entirely SDs (F1 to F9) were compared and estimated to pure Nicardipine Hydrochloride. Solid dispersion with (1:1:1) drug: PEG 6000: Poloxamer 188 ratio showed quicker dissolution. The increase in drug dissolving rate might be recognized to an increase in wettability, the hydrophilic character of the carrier, or a fall in drug crystallinity. Solubility, drug content, dissolution rate, infrared (IR) spectroscopy, & scanning electron microscopy (SEM) tests were conducted on the solid dispersion. Infrared spectroscopy revealed no evidence of substantial drug-carrier interaction (IR). The best formulation in this investigation was a solid dispersion of formulation (F8) Nicardipine Hydrochloride, PEG 6000, and Poloxamer 188 produced in a (1:1:1) ratio that indicated best formulation solubility & a dissolution rate of 99.04% in solid dispersion.