Efficacy of Shatavari Granules in the management of Henoch–Schönlein Purpura (HSP): A single case study

Abstract

Henoch-Schönlein purpura (HSP), the prevailing vasculitis in childhood, manifests through leukocytoclastic vasculitis, predominantly affecting small vessels in the skin, joints, gastrointestinal tract, and kidneys. Its incidence stands at approximately 14-20 cases per 100,000 children annually, exhibiting a higher predilection towards males with a ratio of 1.2-1.8:1 compared to females. Contrarily, HSP manifests less frequently in adults but often accompanies severe and protracted complications. The condition tends to occur more frequently during the winter and spring seasons, while occurrences during summer are uncommon. Clinical manifestations of HSP bear resemblance to Ayurvedic Rakta Pradoshaja Vyadhis, with patients typically presenting symptoms such as vyanga (pigmentation), daha (burning sensation), kandu (itching), rukshata (dryness), raga (redness) over the skin, udarashoola (colicky pain), and sandhi vedana (joint pain).

Aim: The aim of this study is to assess the efficacy of Ayurveda management in treating HSP, known as Raktapradoshajavyadhi, and to elucidate the potential of Ayurveda treatments in addressing autoimmune disorders like HSP.

Objectives: This study aims to document the clinical outcomes of Ayurvedic medicine in the management of Henoch-Schönlein purpura (HSP).

Methods: In this single case study, a 14-year-old female diagnosed with HSP presented with reddish and blackish skin lesions on her upper and lower limbs persisting for four months, accompanied by itching, burning sensation, arthritis, and stomach ache. The patient received Ayurvedic treatment for one month, and observations were made regarding the outcomes.

Results: The patient showed improvement solely with herbal medication. Skin purpura on the lower limbs and abdominal pain, which had not responded to corticosteroid treatment, disappeared and did not recur following Ayurvedic intervention.

Conclusion: This case suggests the potential effectiveness of Shatavari Granules in managing HSP in patients.