Design Synthesis Characterization Of Some Novel Chromane-Based Analogues And Its Antimicrobial Evaluation

Abstract

Because of its diverse variety of pharmacological effects, chromane (4H-benzopyran) is a privileged scaffold in medicinal chemistry. In order to increase antibacterial activity, new chromane-based analogues were created and synthesised for this investigation. The produced compounds' antibacterial ability was assessed against a range of bacterial and fungal strains, and their structural characteristics were assessed through the use of spectroscopic techniques. Significant antibacterial activity was demonstrated by a number of compounds, suggesting that they could be excellent leads for more research. Numerous new compounds based on chromane were created and demonstrated encouraging antibacterial properties. Changes in structure have a major impact on potency. These results serve as a foundation for additional chromane analogue research and optimisation as possible antibacterial agents.