Dissecting Stroke's Intricacies: A Comprehensive Analysis Of Current Developments – A Systematic Review

Abstract

This extensive systematic review discusses recent advances in stroke research from 2015 to 2025, highlighting advancements in molecular mechanism comprehension, diagnostic methods, therapeutic strategies, and rehabilitation advancements. A systematic review of the available literature, consolidating results from more than 50 recent studies and clinical trials, assesses the main areas. Technological improvements in mechanical thrombectomy have shown dramatic effectiveness for large vessel occlusions, with recanalization success rates usually over 70% and a high correlation between prompt intervention and good functional outcomes. The main takeaways include increasing recognition of the dual role of neuroinflammation in injury and repair, the revolutionary effect of mobile stroke units and AI on swift diagnosis, and the development of new-generation neurorehabilitation technologies such as Vagus Nerve Stimulation (VNS), robotics, and brain-computer interfaces. The evaluation emphasizes the continued global burden of stroke in the face of these developments and underscores the imperative need for further innovation, accurate patient stratification, and improved public health measures to prevent stroke-related morbidity and mortality.