Relation of Melatonin, CoenzymeQ10 and AMP Activated protein kinase in postmenopausal women with cardiovascular diseases

Abstract

Background: Cardiovascular disease (CVD) remnants the important cause of morbidity and death among women internationally.

Objective: This study aims to study the relationship between melatonin, coenzyme Q10, and AMP-activated protein kinase (AMPK) in postmenopausal women with CVDs.

Methodology: A case-control study was conducted, involving 90 female participants aged between 53 and 70 years. The sample comprised 60 patients diagnosed with CVD and 30 healthy controls. Samples were collected from August 2024 to December 2024 at Tikrit Teaching Hospital in Tikrit city and Al-alam Hospital. The researcher prepared a data collection sheet used during interviews, which included questions about participants’ age, weight, height, and medical history. The participants all women aged from 53-70 years. A total 60 postmenopausal women with CVDs versus to 30 healthy controls women participants enrolled in the present study. Blood samples were collected at specific time from 10:00pm to 1:00am and analyzed for measurement of melatonin, coenzymeQ10 and AMP activated protein kinase.

Results: Melatonin concentration were significantly lower in the postmenopausal women with CVDs (199.7±80.3 pg\ml) compare to control (366.1±115.1 pg\ml). Coenzyme Q10 level were significantly reduced in postmenopausal women with CVDs (9.7±3.4ng\ml) compare to control (16.7±5.6ng\ml). AMPK level were reduced in postmenopausal women with CVDs (1994.1±881.9pg\ml) compare to control (3236.3±1157.6pg\ml). Conclusions: In postmenopausal women the risk of CVDs will increase with decrease the level of melatonin, coenzymQ10 and AMP activated protein kinase.