The Role Of Thyroid Hormone Receptor Β In Patients With Non-Alcoholic Fatty Liver Disease

Abstract

Background:Nonalcoholic fatty liver disease (NAFLD) includes all phases and grades of the disease. It is defined as a group of people in which at least 5% of hepatocytes display macrovesicular steatosis and there is no clear cause of steatosis, such as alcohol, drugs, malnutrition, or genetic diseases.

About two-thirds of people with type 2 diabetes and high blood pressure and high cholesterol have fat in their livers. Thyroid hormone (TH) is an important factor in how the liver processes glucose, cholesterol, and lipids. Thyroid hormone receptors (THRs) are part of the nuclear receptor superfamily. They act as transcription factors that need ligands to work.

Objective:determine the Role of thyroid hormone receptor β in Patients with NAFLD

Patients and Methods: From June 1, 2024, to June 15, 2025, a study took place at Azadi Teaching Hospital. There were 90 people in the trial, 60 of whom had NAFLD and 30 who were healthy. The study employed a spectrophotometer to measure high-density lipoprotein (HDL), triglyceride (TG), and cholesterol. The ELISA washer and reader can also be used to quantify TSH, THR-β, and thyroid hormones (T3 and T4).

Result:Patients' ages range from 20 to 65 years. Serum level of THR-β was measured and compared to control group, it was significantly lower in patients with NAFLD.Thyroid hormone (T3, T4) also were measured and they were significantly higher in patient group than control group, while TSH level was lower in patients than controls. Measurement of triglyceride and cholesterol reveal higher level in patient than control while HDL level was significantly lower in NAFLD.