Formulation And Characterization Of Lacidipine Containing Transdermal Patches

Abstract

The aim of this study was to formulate and characterize lacidipine-containing transdermal patches using various polymers and excipients, focusing on optimizing the drug release profile and mechanical properties. Lacidipine, a calcium channel blocker, was incorporated into transdermal patches made with a combination of Eudragit L-100, ethyl cellulose, and HPMC as the main polymer matrix. The patches were evaluated for their physical properties such as thickness, moisture content, folding endurance, tensile strength, and drug content. In vitro drug release studies showed that the optimized formulation (F4) exhibited a steady, controlled release of lacidipine over a 12-hour period, with a cumulative drug release of 98.98%. The in vitro diffusion release kinetics followed a zero-order release model (R² = 0.985), suggesting a constant rate of drug release. These findings indicate that the lacidipine transdermal patch provides an effective, controlled release system, making it a promising candidate for improving patient compliance in hypertension management.