Modulatory Effects Of Dimethyl Itaconate And CB2 Receptor Activation On BDNF Expression In Paclitaxel Induced Neuroinflammatory Disorders

Abstract

Brain-Derived Neurotrophic Figure (BDNF) plays a pivotal part in neuroplasticity, neuronal survival, and synaptic balance. however, the dysregulation of this factor, especially its overexpression, is related with different neurological clutters. The Cannabinoid Receptor Type2 (CB2) is perceived as an critical helpful target due to its part in neuroprotection and resistant tweak inside the central apprehensive framework. This study about explores the impacts of CB2 receptor agonists on the overexpression of BDNF using an in vivo demonstrate. Mice gotten treatment with particular CB2 agonists, after which BDNF expression levels were examined utilizing atomic and immunohistochemical strategies. The comes about illustrated that CB2 actuation driven to a diminish in BDNF overexpression, likely through anti-inflammatory instruments and the control of cytokine levels. The comes about recommend that CB2 receptor agonists may serve as potential modulators of BDNF-related neural dysfunctions, advertising a promising restorative pathway for the treatment of neurodegenerative and neuroinflammatory clutters.