Analysis Of The Antimicrobial Activity Of Bacteriophages And Antibiotics Against Staphylococci And Streptococci

Abstract

Aims: This study evaluated the in vitro antimicrobial activity of various antibiotics and a staphylococcal bacteriophage produced by the “Rufag” company (Russia) against Staphylococcus aureus and streptococcal bacteria.

Methodology and results: The study was conducted in 2025 at the multidisciplinary clinic of the Tashkent Medical Academy. Samples of pus were taken from 20 patients in the diabetic purulent surgery department and tested for the presence of staphylococci and streptococci. The lysis zone of the bacteriophage against S. aureus measured 25–27 mm, indicating a high level of antibacterial activity. Among the antibiotics tested, vancomycin (27 mm), levomycetin (27 mm), compound S (26 mm), and cefoperazone+sulbactam (25 mm) were the most effective against streptococci. Several other antibiotics demonstrated limited efficacy.

Conclusion, significance and impact of study: The findings underscore the importance of rational antibiotic selection, the ongoing challenge of antimicrobial resistance, and the potential role of bacteriophage therapy in modern infectious disease management.