The Effect Of Vitamin D SNP Taqi (Rs731236) On Axil Spondylarthritis Disease In Patient On Biology Treatment

Abstract

In Axil spondylarthritis (AxSpA ) disease was found increased in the level of tumour necrosis factor that produced mainly from immune cell like T cell and B cell where found in many study that tumour necrosis factor (TNF) play a major role in AxSpA development leading to increased disease  activity even that take biological treatment like infliximab that supposed be TNF blocked, That where leading to another cases related to genetic type, SNP TaqI was found have effect on disease activity in patient with these SNP. Objectives: The vitamin D receptor (VDR) modulates the expression of different genes that are involved in various cell processes. Abnormality in expression and genetic polymorphism of VDR are related to Axil spondylarthritis disease (AxSpA) . also, the effect on the biological treatment (infliximab) that patients take it. Therefore, we investigated the association between the genetic polymorphism of VDR TaqI and infliximab treatment  in AxSpA. Patients , Materials and methods: The study design is cross sectional study .The genotyping of VDR (TaqI ) polymorphism was performed using  PCR-RFLP in 150 AxSpA patients included male (108) and female (42) on biological treatment for at least 3 months, where this study done in Rheumatology Clinics of Baghdad Hospital, Medical City, Baghdad- Iraq with ethical approval from Department of Biochemistry, College of Medicine, Baghdad University. Result:  SNP found in this study have relationship with disease activity in patient with these TaqI SNP , where found in this study significant relationship between Taq genotype and disease stage  variant show statistical significant association with active disease from different stages, 87.5% of patients with very high disease activity had TC genotype, 66.7% of patients with high disease activity had TC genotype and 73.9% of patients with low disease activity had TC genotype.