FLAVONOIDS IN ECOTOXICOLOGICAL CONTEXT. THE HYDROPHOBICITY ROLE IN COMMON QSARs

Abstract

 The naturally occurring flavonoids are be the primary focus of this review, with occasional reference
 to synthetic compounds; although not exhaustive, it is intended to acquaint the reader with this interesting
 group of natural plant compounds, since there has been in recent years a major rekindling of interest in
 pharmacognosy, while flavonoids turn out to be present in many natural therapeutically utilized products.
 Appropriate discussion on chemical-biological interaction was as well presented within the quantitative
 structure-activity relationship analysis, with which occasion the Non-Gaussian-Leave-Out method of
 molecular screening was adopted, while emphasizing on the role of hydrophobicity, of it order dependence
 and of the structural electronic factors in providing acceptable Multilinear correlations.