Formulation, Development And Evalution Of Roflumilast Psoriasis Gel

Abstract

Effective symptom management for psoriasis, a chronic, immune-mediated inflammatory skin condition, necessitates tailored and consistent medication delivery. The formulation, creation, and assessment of a topical gel based on Roflumilast for the treatment of psoriasis using an emulsion-based delivery system are the main objectives of this study. Roflumilast is a viable topical treatment option because it is a selective phosphodiesterase-4 (PDE4) inhibitor with strong anti-inflammatory effects. In order to improve drug solubility, stability, and epidermal penetration, an oil-in-water emulsion gel was created. The generated gel's physicochemical properties, including its drug content, pH, viscosity, and spreadability, were evaluated. In vitro drug release tests were performed to assess the formulation's efficacy.

Consistency, homogeneity, and controlled drug release were all excellent outcomes of the optimized emulgel, suggesting that it could be a successful topical treatment for psoriasis. To assess the effectiveness and safety of the treatment, more in vivo research is advised.