Absorption And Phytotoxic Effects Of Expired And NonExpired Paracip And Ranglim VG1 Tablets On Trigonella Foenum-Graecum

Abstract

Among the various class of drugs, the antidiabetics and acetaminophen are one such group of pharmaceuticals that has got greater usage in the current scenario. The improper disposal of these medicines after expiry and unused has become a concerning environmental issue. This research is focused on determining the toxic impacts of expired and non-expired Paracip and Ranglim tablets on the plant growth parameters and residue absorption using Trigonella foenum-graecum. For the toxicity study, both the expired and non-expired paracip and ranglim tablets were powdered and added at the rate of 1g, 5g and 10g to the soil sample. The fenugreek seeds were added to the soil and kept for observation. A tracer amount of water was added regularly. After the complete growth of plants, the growth parameters were evaluated. In order to assess the translocation of both the tablets, the percentage absorption through the root and shoot system were analysed. The root and shoot of both the samples were dried, powdered and extracted. Later, it was subjected to LC/MS analysis. From the experimental result, it was found that, the expired paracip and ranglim treatments, resulted in decreased germination percentage in comparison with the control and non-expired treatments. In 10g concentration of expired paracip treatment, none of the seed were germinated. From the LC/MS result, it was found that, the maximum percentage of the expired paracip (0.063) was observed in 1g concentration in shoot part of the plant. Whereas in case of ranglim LC/MS result, it was shown that, the maximum percentage absorption was observed in 5g concentration of the expired ranglim (6.83%) treatment in root part of the plant. The proper disposal of the expired tablets is essential to avoid the residual absorption and minimize the risk of growth inhibition.