Evaluation Of Colonic Mucosa Of Non-IBS / Non-Endoscopic Large Bowel Disorders In Diabetes Mellitus And Bronchial Asthma

Abstract

Background: Irritable-Bowel-Syndrome (IBS) is a functional gastrointestinal disorder that affects a considerable percentage of population. Diabetes Meletus (DM) and Bronchial Asthma (BA) share similar symptomatology. 

Objective: our study aimed to assess histopathologic changes of colonic mucosa of IBS compared to non-IBS patients in Diabetics and Asthmatics.

Subjects and Methods: All populations (n=250) had free colonoscopic screening. They were classified into diabetics (n=74), asthmatic (n=58) and no. DM/no.BA (n=118). Each group is divided into IBS and non-IBS subgroups. They were submitted to colonoscopy and mucosal biopsy. Mucosal-lymphocytic-infiltration (MLCI) was graded according to number of cells per high-power-field (HPF) into average(<10cells/HPF), mild (10 to 30cells/HPF), and moderate(>30cell/HPF). Mucosal-bacterial-invasion (MBI) was also graded into no microorganism(0/HPF), few microorganisms(<10/HPF), and moderate number of microorganisms(≥10/HPF).

Results: The average MLCI showed close frequencies in the IBS subgroups of diabetics (74.3 %), asthmatics (84.4 %), and no. DM/no.BA (91.5 %) groups (P>0.05). The non-IBS population in both DM (13.5%) and BA (8.6 %) showed significantly increased frequency of average MCLI when compared with no. DM/no.BA population (4.23 %) (P<0,05). Absent colonic MBI in IBS showed insignificant variation in DM (74.3 %), BA (82.7 %), and no. DM/no.BA (94.06 %) (P>0.05). The non-IBS population in DM group (20.72%) had significantly increased frequency of invasion with few microorganisms when compared with no. DM/no.BA populations (4.2 %) (P<0,05), but not with asthmatic patients (10.54 %) (P>0.05).

Conclusion: Average colonic MLCI is found in non-IBS patients who have Diabetes-Meletus and bronchial asthma. Low levels of Mucosal-Bacterial-Invasion is only seen in the none-IBS asthmatic patients.