Evaluation Of Gastro-Duodenal Mucosa Of Non-IBS / Non-Endoscopic EGD Disorders In Diabetes Mellitus And Bronchial Asthma

Abstract

Background: Irritable bowel syndrome (IBS) affects a large portion of the world's population. Diabetes Mellitus (DM) and Bronchial Asthma (BA) induce a broad spectrum of clinical GIT manifestations. 

Objective: Assessing the histopathologic changes of the Gastro-Duodenal mucosa of IBS compared to non-IBS patients in Diabetics and Asthmatics.

Subjects and Methods: Study populations (n = 351) underwent free gastroscopic screening and were divided into three groups: diabetics (n = 84), asthmatics (n = 70), and non-asthmatics non-diabetics (n=197); each of them was subdivided into IBS and non-IBS. Mucosal-lymphocytic infiltration (MLCI) was graded into average (< 10 cells/HPF), mild (10 to 30 cells/HPF), and moderate (> 30 cells/HPF). Mucosal bacterial invasion (MBI) was also graded into no microorganism (0/HPF), few microorganisms (<10/HPF), moderate number of microorganisms (≥10/HPF).

Results: The average (<10cells/HPF) MLCI was significant in the IBS category of no. DM/no.BA compared to that of diabetics (P=0.008) and asthmatics (P=0.021). Moderate (>30 cells/HPF) MLCI was more frequent in non-IBS patients with DM (P=0.044) and BA (P=0.086) compared to those no. DM/no.BA group. The IBS cases in no.DM/no. The BA subgroup had a significantly increased frequency of no bacterial invasion compared to diabetics (P = 0.003) and asthmatics (P = 0.02). The non-IBS cases with bronchial asthma showed a significantly increased frequency of MBI with a moderate number of microorganisms (≥10/HPF) compared to those without.DM/no.BA subgroup (P=0.0147).

Conclusion: Moderate (>30 cells/HPF) gastro-duodenal Mucosal-Lymphocytic-Infiltration is found in non-IBS patients who have Diabetes-Mellitus and Bronchial Asthma, while moderate Mucosal-Bacterial-Invasion (≥10/HPF) is seen only in Bronchial Asthma.