Synthesis and Antimicrobial Evaluation of Novel Triazole Based Pyrazole Derivatives

Abstract

Pyrazole is well-known intermediate in the synthesis of a wide range of biologically active heterocyclic compounds, including imidazoles, pyrazoles, and pyrimidines. Additionally, they play a vital role in the construction of various bioactive scaffolds such as flavones, flavanols, anthocyanins, pyrazolines, benzal coumarones, deoxybenzoins, and hydantoins. In the present work, novel triazole-based pyrazole derivatives were synthesized through the reaction of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide with a series of aromatic aldehydes, resulting in the formation of chalcone intermediates. These intermediates were subsequently reacted with 4H-1,2,4-triazole-3-amine to obtain a new series of triazole-linked pyrazoles. The structures of all synthesized compounds were confirmed through various spectroscopic methods and evaluated for their antimicrobial activity against both gram-positive and gram-negative bacterial strains.