Pharmacological Evaluation Of Dolichandrone Falcate Extract For Gastro-Protective Activity

Abstract

Gastric ulcer is a common treatable clinical situation which affects patient quality of life and causes economic burdens on the health care system. It occurs due to weakened defensive mechanisms in gastric mucosa. Changing lifestyles, including smoking, alcohol consumption, over the counter use of NSAIDs, and H. pylori infection have increased the prevalence of gastric ulcers. Alcoholics have the risk of upper gastrointestinal bleeding compared to non-alcoholics, and this risk is further potentiated with the concurrent use of NSAIDs. Alcohol causes congestion, hemorrhagic lesions with microvascular damage, oedema, and exfoliation of the epithelium. The main aim of this research work is to investigate the gastroprotective, studies of Dolichandrone Falcate.