Phytochemical And Pharmacological Evaluation Of Vitex Peduncularis For Management Of Liver Dysfunction

Abstract

Liver illnesses are still the serious problem of human health. Paracetamol is a common analgesic and antipyretic drug. Several studies have demonstrated the induction of hepatocellular damage or necrosis by acetaminophen higher doses in experimental animals and humans. Vitex Peduncularis is a moderate sized tree found in Bangladesh, India and many other countries. The plants are known to produce certain bioactive molecules which react with other organisms in the environment and in turn cause the inhibition of bacterial or fungal growth. Vitex Peduncularis will be useful for different types of diseases like inflammation, ulcer, wound, diabetic wound. The objective of the present study is to establish efficacy of Vitex Peduncularis for treatment of liver dysfunctioning. From our results, it can be concluded that decrease levels of catalase, and increased serum marker enzymes and lipid peroxidation level in paracetamol treated animals was due to hepatocellular damage. Methanol extract of Vitex Peduncularis afforded protection from such paracetamol induced liver damage, and has shown the most pronounced hepatoprotective effect.