Formulation And Characterization Of Nanocarriers Bearing Lopinavir Emulsome

Abstract

Nanocarriers, with their tunable surface characteristics and internal structures, offer enhanced delivery options for both small-molecule drugs and biologics. In recent years, research has emphasized the design of specific nanocarriers to minimize systemic exposure and reduce unintended side effects. The suggested study set out to create a carrier technology that might carry lopinavir topically without causing any side effects or toxicity. Nanocarrier emulsomes has the potential to increase drug solubility and bioavailability, decrease dosage requirements, and enhance pharmacological activity. Particle size, and by extension, PDI and zetapotential action, are positively correlated with solid core concentration and lipid content, according to the results. To optimize the impact of different surfactants at varied concentrations to identify the penetration rate or drug entrapment efficiency within the solid lipid core, the results of all dependent variables led to the selection of formulation LEMs4.