SYNTHESIS OF NOVEL BENZAZEPINE DERIVETIVE AND THERE BIOLOGICAL SCREENING

Abstract

This study focuses on the synthesis and comprehensive characterization of novel benzazepine derivatives, a class of compounds with potential pharmaceutical applications. The synthesis was carried out using [2-amino-3-(4-bromobenzoyl) phenyl]acetic acid (1) and a diverse range of ketones as starting materials. The reaction was performed under optimized conditions in aqueous sodium hydroxide solution to obtain the desired benzazepine derivatives with high yield and purity. A series of new compounds (5a to 5i) were successfully synthesized through this method, showcasing the versatility and efficiency of the synthetic approach. The newly synthesized benzazepine derivatives were thoroughly characterized using a combination of advanced spectroscopic techniques. Infrared (IR) spectroscopy was employed to identify key functional groups and structural features. Mass spectrometry provided accurate molecular mass information and fragmentation patterns, confirming the molecular composition of the synthesized compounds. Proton nuclear magnetic resonance (1H-NMR) spectroscopy was utilized to elucidate the detailed structural arrangements and confirm the presence of specific proton environments within the molecules. The structural elucidation of these newly synthesized derivatives provides valuable insights into their chemical properties, including electronic distribution, bond characteristics, and potential reactivity. This comprehensive characterization not only confirms the success of the synthetic methodology but also lays the foundation for understanding the structure-activity relationships of these compounds. Furthermore, this research significantly contributes to the expansion of the benzazepine scaffold, a structural motif of considerable interest in medicinal chemistry. The diversity of the synthesized compounds (5a to 5i) demonstrates the potential for generating a library of structurally related benzazepine derivatives with varied substituents. This structural diversity may have important implications for pharmaceutical development, as it allows for the exploration of a wider chemical space in the search for compounds with desirable biological activities. The successful synthesis and characterization of these novel benzazepine derivatives open up new avenues for further research in medicinal chemistry. These compounds may serve as potential lead structures for the development of new therapeutic agents, particularly in areas where benzazepine-based drugs have shown promise, such as in the treatment of neurological disorders or as anti-inflammatory agents. In conclusion, this study presents a robust synthetic methodology for novel benzazepine derivatives, coupled with comprehensive spectroscopic characterization. The findings contribute significantly to the field of heterocyclic chemistry and provide a solid foundation for future investigations into the biological activities and potential pharmaceutical applications of these compounds. Keywords: Benzazepine derivatives, ketone, [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid, spectroscopic characterization, medicinal chemistry, heterocyclic compounds, structure-activity relationships, pharmaceutical development.ization and Model Tuning Newly synthesized derivatives (5a to 5i) have been evaluated on the basis of spectral and analytical data like IR, mass and ¹H-NMR spectroscopy.