Design And Two-Step Synthesis, Characterization Of 1,2,3-Triazol-Benzo- Oxazolo And Benzo-Imidazo [1,8] Naphthyridines

Abstract

Herein, we have depicted  the two step series of phenyl-1H-1,2,3-triazol-1-yl) phenyl) benzo[b]oxazolo[5,4-f] [1,8] naphthyridines 4a-4i & phenyl-1H-1,2,3-triazol-1-yl) phenyl)-1H-benzo[b]imidazo[4,5-f] [1,8] naphthyridines 7a-7i through azide formation followed [3+2] click protocol cyclo addition with various terminal alkynes 3a-3i   by means of CuSO₄.5H₂O and sodium ascorbate namely  Sharpless catalyst to give promising yields, shown in Scheme I & II and further confirmed by spectral and elemental analysis.