Development And Optimization Of Gold Nanoparticle Synthesis From Bauhinia Purpurea Extracts

Abstract

Objective:

This study shows how to easily make gold nanoparticles (AuNPs) using Bauhinia Purpurea extracts a simple and green approach.

Method:

This method offers a biocompatible, economical, and environmentally friendly method without hazardous chemicals. A central composite design (CCD) was used to find the best way to make nanoparticles, adjusting the quantity  of Bauhinia Purpurea  Extract  quantity of Hypochloro aureate and the incubation time to see how they all worked together. Samples of the mixture were taken every hour to track the development of nanoparticles using the UV–Vis spectrophotometer. The reaction mixture gradually turned from dark green to mulberry hue within the first 0.5 to 3 Hr, signaling the formation of AuNPs.

Results:

We found that using 5.5 ml of Extract, 5.5 ml Hypochloro aureate  and a 1.25 h incubation period produced the most AuNPs. Optimized formulation further tests, including UV–Vis spectroscopy, DLS, XRD, FTIR, SEM, and DSC, showed that these nanoparticles were generally spherical, with an average size of 31.96 nm. The sample also had a good PDI of 0.293, and the powder was mostly made up of a highly crystalline Au–3C gold phase (70.8%). Antiarthritic  studies revealed that the synthesized AuNPs exhibited significant inhibitory activity against standard diclofenac sodium.  

Conclusion:

This research shows that Bauhinia Purpurea  extract can be used to create AuNPs in an environmentally friendly way. These AuNPs show promise for fighting arthritis. The statistical optimization model revealed that 5.5ml of HAucl4, 5.5 ml of extract and 1.25 Hr time is optimum condition to synthesize a higher yield of AuNPs.