Bigel-Based Transdermal Delivery Of Ketoprofen And Tulsi Oil: A Synergistic Approach For Effective Inflammation Control

Abstract

This study investigates the development of ketoprofen bigel for transdermal route to reduce the inflammation by using HPMC K100 (hydroxypropyl methyl cellulose) based hydrogel and carbopol 930 based oleogel with Tulsi oil. Tulsi oil has analgesic and anti-inflammatory activity, menthol is also added in the formulation to give a cooling sensation, increasing blood flow and pain reduction. Upon exhaustive research, the transdermal drug delivery system (TDDS) has appeared as a potential, widely accepted, and popular approach to a novel drug delivery system. Ease of administration, easy handling, minimum systemic exposure, least discomfort, prolonged therapeutic effect; make it a promising approach for drug delivery. All prepared formulations were evaluated for In-vitro diffusion study using cellulose acetate membrane. Ex-vivo study is carried out using rat’s abdominal skin. The desired drug release was obtained by optimized preparation, which contains 2.5% ketoprofen. All the prepared formulations showed good apperance. The spreadability results obtained were in correlation to the amount of polymers being added.  Higher polymer concentration resulted in higher viscosity, resulting in poor spreadability and extrudability.  Drug release from the bigel was 70.68 – 95.72% after 4 hours of study. Different batches were having the PH 5.11– 6.50.