Novel Synthetic Approaches and Biological Evaluation of Quinoline Derivatives for Antimicrobial Resistance

Abstract

As Quinoline derivatives exhibit various mechanisms of action such as DNA synthesis inhibition, membrane integrity disordering, and reactive oxygen species generation, they become important agents in the battle against antimicrobial resistance. The present review focuses on the importance of quinoline derivatives in combating antimicrobial resistance, as well as summarizes the key structural attributes responsible for their potency and discusses Structure-Activity Relationship (SAR) studies important towards tailoring these scaffolds. Highlights of the study involve the discovery of crucial substituents, hydrophobicity, and electron supply effectiveness in augmentation to antimicrobial activity and opportunities for new SAR approaches to find novel medications.