Evaluation Of The Impact Of Paternal Sperm DNA Quality And Maternal Follicular And Hormonal Parameters On Intrauterine Insemination (IUI) Outcomes In Infertile Couples In Kirkuk City, Iraq

Abstract

The success of intrauterine insemination (IUI) depends on several factors, including endocrine function, hormonal balance, the number and size of the oocytes in the wife, and the sperm quality of the husband. Therefore, evaluating infertile couples before initiating treatment is essential to avoid unnecessary procedure

Aim of Study:The present study aimed to investigate the impact of paternal sperm DNA quality, follicular parameters such as the number and size of follicles on the day of insemination, and maternal hormonal factors including FSH, LH, progesterone, and AMH on IUI outcomes among some infertile couples, in order to improve IUI management in the community of Kirkuk, Iraq, where such research remains limited.                                     

Methods: The present study included 96 infertile couples during the period from December 2023 to February 2025. Paternal sperm DNA quality, as well as maternal follicular and hormonal parameters, were assessed. Appropriate statistical analysis tools were applied

Results: The results showed significant differences in paternal DNA fragmentation, oocyte size, and FSH levels across all age groups in couples who responded to intrauterine insemination (IUI) compared to non-responders. However, no significant differences were observed in AMH levels or the number of oocytes across all age groups.

Conclusion: The pregnancy rate decreases with the reduction in oocyte size and FSH levels, which negatively affects the response to intrauterine insemination (IUI) in infertile women.

Conclusion: Oocyte size and FSH concentration affect the outcomes of IUI; therefore, these conditions should be addressed before initiating treatment with assisted reproductive techniques.