Evaluation Of The Antihyperlipidemic And Anti Oxidant Activity Of Albizia Lebbeck Extract In Wistar Rats

Abstract

Background: Hyperlipidemia is a chronic metabolic disorder associated with cardiovascular complications including atherosclerosis, ischemic heart disease, and myocardial infarction. Despite the availability of synthetic lipid-lowering agents, their long-term use is limited due to side effects and cost.

Objective: The present study investigates the antihyperlipidemic and antioxidant potential of Albizia lebbeck seed extract in experimental Wistar rats.

Methods: Albizia lebbeck seeds were extracted using ethyl acetate in a Soxhlet apparatus. Physicochemical and phytochemical evaluations were performed, including TLC and FTIR analyses. Acute and sub-acute toxicity studies were conducted following OECD guidelines. Hyperlipidemia was induced in Wistar rats using a high-fat, high-fructose diet, followed by administration of the extract at different doses (500, 1500, and 2000 mg/kg).

Results: Phytochemical screening confirmed the presence of flavonoids, alkaloids, glycosides, and saponins. Toxicity studies revealed no adverse effects on body weight, food/water intake, hematological or biochemical parameters, or organ histopathology. Treatment with A. lebbeck significantly reduced serum cholesterol, triglycerides, LDL, and VLDL levels, while increasing HDL.

Conclusion: Albizia lebbeck seed extract demonstrated significant antihyperlipidemic and antioxidant activity without notable toxicity, suggesting its potential as a safe herbal therapeutic.