Hyphenated Techniques In Debasement Profiling Of Efavirenz: A Survey Of LC-MS, NMR, And HPLC Applications

Abstract

Getting contaminants right-from identification to assessment-is essential for drug quality and safety. Even tiny amounts can dramatically affect a medicine's effectiveness and carry serious risks, including toxicity and possible carcinogenic effects. Contaminant profiling means identifying, characterizing, and measuring pollutants at every stage of drug development. Advanced analytical methods-like liquid chromatography and mass spectrometry-are essential for accurate detection and quantification. Regulatory guidelines lay out how to spot and manage contaminants to boost drug safety. Techniques such as crystallization and chromatography play a key role in purifying products and removing harmful contaminants. Understanding where contaminants come from and how they travel is critical for building effective control measures. Ongoing research in advanced analytical methods, together with strict regulatory compliance, is vital for keeping pharmaceutical products safe and effective.