New Insights into 1,2,4-Triazole-3-Thiol Chemistry: Synthesis and Tuberculostatic Activity

Abstract

Background: Tuberculosis (TB), a formidable global health crisis, relentlessly claims countless lives annually, perpetuating widespread morbidity and mortality. The dire need for groundbreaking treatments has ignited fervent research into innovative therapeutic paradigms. Materials and Methods: This pioneering study embarked on synthesizing an array of benzimidazole derivatives, rigorously evaluated for their antimicrobial prowess through the cutting-edge Microplate Alamar Blue Assay. This sophisticated method meticulously determined the Minimum Inhibitory Concentration (MIC) against the formidable Mycobacterium tuberculosis H37Rv strain, setting a new benchmark for precision in anti-tubercular research. Results: From this ambitious endeavour, 1,2,4-triaole derivatives 3 emerged as titans, showcasing unparalleled potency against M. tuberculosis. Their remarkable anti-tubercular activity signals a monumental leap forward in combating this relentless pathogen. Conclusion: This trailblazing study emphatically validates the transformative power of synthetic chemistry in sculpting novel anti-tubercular agents. The extraordinary efficacy of compounds 3 heralds their potential as revolutionary therapeutic frontrunners, poised to redefine TB treatment landscapes. These findings galvanize further exploration and clinical scrutiny, promising to alleviate the global TB burden and usher in a new era of hope for millions afflicted by this devastating disease.