Exploring The Antioxidant Potential of Angaya Chooranam: Investigating Mechanism of Action in Siddha Medicine

Abstract

Siddha medicine is one of the oldest medical systems in the world. It originated in Southern part of Tamilnadu. Traditional Siddha medicines are recently attaining worldwide acceptance for its health benefits, rejuvenation and synergistic properties, less side effects, cost effectiveness and it is easily available. ‘Angaya Chooranam’ comes under the division ‘Kaya karpam’. The word “Kayakarpam” means the Prevention of body from diseases. Gastric ulcer is caused by an imbalance between the action of aggressive and defensive factors on the gastric mucosa. Gastric mucosal damage can be induced by aggressive factors such as hydrochloric acid, pepsin, leukotrienes, free radicals, nonsteroidal anti-inflammatory drugs (NSAIDs), ischemia, dysmotility, ethanol, nicotine, and stress. In this research article Gastric ulcer correlated with the Angaya Chooranam Anti-Oxidant property. Angaya Chooranam (AC) was prepared as per the Siddha literature Marunthu Sei Iyalum Kalaiyum. “Angayam” is a thogai sarakku which possess mainly 5 ingredients: Mustard, Asafoetida, Fenugreek, Garlic and Ajwain. In traditional preparation method dried Neem flowers, dried Turkey berries, and dried black night shade fruits are added to it. Angaya Chooranam is a Siddha poly herbal formulation containing about eight herbal Ingredients indicated for treating gastric ulcer, improves appetite, heals mouth ulcers and expels intestinal worms. The above herbs listed in this article does contain free radical scavenging activity, due to its total phenolic content, a potent anti-oxidant relating to the concept of kaya karpam regimen stated in Siddha literatures thereby leading to anti-ageing effect. This research paper exhibits in vitro Anti-oxidant activity of the test drug Angaya Chooranam through DPPH (2, 2-Diphenyl 1-2 picrylhydrazyl), Nitric Oxide Radical Scavenging, ABTS, Hydrogen Peroxide Radical Scavenging activities and the results show significant free radical scavenging properties.