Association of Triglyceride/High-Density Lipoprotein Cholestrol (Tg\Hdl-C) Ratio and Triglyceride-Glucose (Tyg) Index with Hba1c in Patients with Type 2 Diabetes Mellitus - A Retrospective Study

Abstract

Background: One of the most prevalent non-communicable diseases worldwide, including in India, is diabetes mellitus (DM), which is also a major public health concern. Hyperglycemia, or elevated blood glucose levels, is a hallmark of this chronic metabolic disorder that results from either insufficient insulin action or synthesis, or both. Microvascular and macrovascular problems include diabetic nephropathy, retinopathy and neuropathy, coronary artery disease, peripheral arterial disease, and stroke can develop early if type 2 diabetes is left untreated and uncontrolled. Triglyceride-glucose index (TyG index) calculated according to fasting blood glucose (FBG) and triglyceride (TG) measurements can also be used as an indicator of insulin resistance. The aim of this study was to evaluate the association of TG/HDL-C ratio and TyG index with glycated hemoglobin levels in Type 2 diabetic patients.

Materials and Methods: The current research investigated Serum lipid profile, TyG index, TG/HDL-C and glycemic status to examine different metabolic alterations in Type 2 DM patients with good glycemic control compared to poor glycemic control. Standard methods were followed.

Results: TyG index was higher in patients with poor glycemic control (HbA1c≥7%) compared to patients with good glycemic control (HbA1c<7%). TyG index are positively associated with HbA1c levels in Type 2 DM patients.