Prediction Role Of Some Cytokines, Hormones Parameters In Chronic Of Liver Diseases

Abstract

Background: There are several different liver disorders and illnesses. Some are brought on by viruses, such as hepatitis. Others may be brought on by using drugs or consuming excessive alcohol. Cirrhosis may result from chronic liver damage or scar tissue. One indication of liver illness is jaundice, or yellowing of the skin.

Aim: study to determine the predictive role of IL-12, TNF-a, erythropoietin, vitamin D3 and insulin markers in chronic liver diseases in Iraqi patients.

Methods: Diyala's Khanaqin Teaching Hospital conducted the study from January to March 2023. Khanaqin Teaching Hospital's advising unit consultant doctor diagnosed 50 liver failure patients' blood samples. Healthy people gave 30 blood samples as controls. ELISA (Diaclone Research, Besancon, France) measured serum IL-12, TNF-a, Erythropoietin, and Insulin. I-chroma equipment for human serum vitamin D3 fluorescence immune-assay. We evaluated our data with SPSS 24.0 and Graph Pad Prism 10.

Results: The study found higher disease prevalence in males (66.0%) compared to females (34.0%), higher rates in 51-60 and 61-70 age groups (24.0% and 32.0%), and lower prevalence in non-obese liver patients (24.0%) compared to obese patients (76.0%), with significant differences (p<0.05) among gender, Patients had significantly greater levels of IL-12, TNF-a, Erythropoietin, and Insulin indicators compared to healthy persons (p<0.05).In contrast, people with liver failure had considerably lower vitamin D3 levels (p<0.05) than healthy individuals. Above markers were unaffected by age, weight, or gender. The ROC curve concluded that liver disease indicators are sensitive and specific. Liver failure risk variables included gender, age, and obesity. Due to high sensitivity and specificity in diagnosing chronic liver disorders, IL-12, TNF-a, erythropoietin, vitamin D3, and insulin indicators are involved in pathogenesis.