Synthesis, Characterization, In Vitro Antioxidant Activity And In Silico Study On Potential Inhibitory Action Of Novel Curcumin Acquired Copper (II) Complexes Against COVID-19 Main Protease(Mpro:6LU7)
DOI:
https://doi.org/10.64252/d13qbb64Keywords:
Curcumin derivatives, Molecular docking, Antioxidant activity ,Sars- CoV -2 , 6LU7.Abstract
A series of three novel curcumin acquired hydrazone Schiff base copper (II) coordination complexes were synthesized by template method using Curcumin, 2- hydrazine hydrazide and copper salts ( copper chloride ,acetate and sulphate in 2:1 molar ratio. All synthesised derivatives have been characterized by elemental analysis, molar conductance ,thermogravimatric analysis , UV-Vis, FT-IR .On the basis of physico-chemical measurements the following empirical formula have been assigned to the copper (II) coordination compound [Cu (H2L)2 Cl2]. 2H2O, [Cu (H2L)2 (SO4)2].5H2O, [Cu (H2L)2 (CH3 COO)2 ]5H2O where H2L is Hydrazone Schiff base ligand. Total antioxidant activity were tested via DPPH method and this antioxidant activity was appraise by comparison with standard substance like DPPH. The result of antioxidant activity showed that coordinate copper complexes are more influential antioxidant agents than curcurmin acquired hydrazone Schiff base ligand. Molecular docking studies were carried out to ascertain the inhibitory action of studied ligand and its copper (II) complex against the Main protease (6LU7) of novel coronavirus (COVID-19).The result of the docking of ligand and copper complex showed a significant inhibitory action against the Main protease (M pro) of SARS-CoV-2 and the binding energy (∆G) values of the ligand and coordinated complexes against the protein 6LU7 have found to be -8.7Kcal/mol & -9.5 Kcal/mol .
