Influence of Cytisine Derivatives and Succinic Acid Combination on Acute Alcohol and Hypnotic Drug Intoxication in Rats

Abstract

Succinic acid (SA) containing remedies belong to drugs of a metabolic type of action, the pharmacotherapeutic effects of which are aimed at restoring biochemical metabolic reactions disturbed by pathological processes. Alcoholic coma is often accompanied by respiratory failure. The purpose of this work is to study the effect of combinations of cytisine, N-methylcytisine and benzylcytisine with succinic acid in a ratio of 1:1 on the acute alcohol poisoning. The studied compositions have an antitoxic effect in moderate alcohol poisoning. Thus, SA 10 mg/kg reduces the duration of narcotic sleep by 40%, cytisine at a dose of 0.1 mg/kg - by 66.6%, and the composition "cytisine:SA" - by 74.6%. Compositions "N-methylcytisine:SA" and "N-benzylcytisine:SA" at a dose of 0.1 mg/kg - by 35.2 and 41.3%, respectively, yielding to cytisine, SA and their composition, but showing a significant reduction in the narcotic sleep duration.