Evaluation of Anti-Inflammatory Activity of Celosia Cristata Linn. Extract Invitro Study

Abstract

Inflammation is a complex biological response to harmful stimuli, and its dysregulation is implicated in various chronic diseases. The present study aims to evaluate the in vitro anti- inflammatory activity of Celosia cristata Linn. extract, a traditionally used medicinal plant known for its ethnopharmacological properties. Methanolic extract of the aerial parts of Celosia cristata was prepared and subjected to anti-inflammatory screening using protein denaturation assay and membrane stabilization method, two well-established in vitro models. The extract was tested at various concentrations and compared against standard anti-inflammatory drug, diclofenac sodium. The results demonstrated that the plant extract exhibited dose-dependent inhibition of protein denaturation and erythrocyte membrane lysis, indicating significant anti-inflammatory potential. The observed activity is attributed to the presence of bioactive phytoconstituents such as flavonoids, tannins, and saponins identified in the preliminary phytochemical analysis. These findings suggest that Celosia cristata Linn. possesses promising anti-inflammatory activity and may serve as a potential source for the development of natural anti-inflammatory agents.