A Study of Bacteriological Profile and its Antibiogram in Respiratory Tract Infections Among the Patients Attending Tertiary Care Teaching Hospital, Greater Noida

Abstract

Introduction: Respiratory tract infections (RTIs) is a major health problem, particularly in developing nations. They include upper and lower RTIs, with bacterial pathogens playing a significant role in lower RTIs. Rising antimicrobial resistance (AMR) necessitates continuous surveillance of local bacterial profiles and their susceptibility patterns.

Aim and Objective: A study of bacteriological profile and its antibiogram in respiratory tract infections among the patients attending tertiary care teaching hospital ,greater noida.

Method: A cross-sectional study was done over 12 months at a tertiary care hospital in Greater Noida. A total of 108 culture-positive respiratory samples from OPD, IPD, and ICU patients were analyzed. Standard microbiological methods were used for bacterial identification and antimicrobial susceptibility testing via Kirby-Bauer disc diffusion method, following CLSI 2024 guidelines.

Result: Of 229 samples, 108 (47.2%) showed bacterial growth. LRTIs accounted for 96 (88.9%) isolates and URTIs 12 (11.1%). Sputum was the most common sample (43.5%). Gram-negative bacilli predominated (71.9%), with Klebsiella pneumoniae (27.1%) being the most frequent. MRSA was identified in 10 of 17 Staphylococcus aureus isolates (58.8%). Among 108 isolates, 41 (38.0%) were multidrug-resistant, mainly Gram-negative organisms.

Conclusion: The study shows a high prevalence of LRTIs and multidrug-resistant Gram-negative organisms. Empirical antibiotic policies should consider local resistance patterns, with emphasis on rational antibiotic use to mitigate AMR.