Pharmacological Evaluation Of Neuroprotective Effects Of Rubus Ellipticus Against Aluminum Chloride-Induced Memory Impairment In Rats

Abstract

Alzheimer’s disease is the most prevalent kind of dementia and is distinguished by a mild, unrecognized memory loss (also known as "moderate cognitive impairment"). Dementia is a pattern of memory loss and cognitive decline that impacts two or more cognitive domains in an individual The current study investigates the therapeutic efficacy of Rubus ellipticus methanolic extract in a aluminium chloride-induced memory impairment in rat model. Aluminium chloride was administered orally for 21 days to induce alzheimer, followed by treatment with Rubus ellipticus extract at doses of 200 mg/kg and 400 mg/kg. Donepezil served as the standard comparator.

Parameters including elevated plus maze, morris water maze and actophotometer were monitored. Histopathological assessment of brain tissue was also performed. The extract at 400 mg/kg significantly reversed alzheimer -associated alterations, as evidenced by decrease AChE activity and restoration of acetylcholine levels is believed to contribute to the improvement of cognitive functions. 

Phytoconstituents in Rubus ellipticus, such as flavonoids, polyphenols, anthocyanins, tannins and terpenoids, likely mediated its anti- depressant anti- microbial and antioxidant effects. The methanolic extract’s  efficacy was dose-dependent and comparable to Donepezil.

Overall, this study highlights the multifactorial efficacy of Rubus ellipticus in managing alzheimer and supports its potential as a phytotherapeutic alternative to conventional treatments.