Evaluation of Antimicrobial and Antibiofilm Potential of Syzygium diospyrifolium (Wall. Ex Duthie) S.N. Mitra via In Vitro Assays and Molecular Docking Against Bacterial Pathogens..

Abstract

The progressive insensitivity of pathogenic bacteria to antimicrobial agents to conventional treatments it is demands the search for unconventional antimicrobial agents from natural source. In this investigation the leaf and fruit of Syzygiumdiospyrifolium(Wall.ExDuthie) S.N.Mitra were evaluated for their antimicrobial and antibiofilm activities against pathogenic bacteria, S.aureus, B.subtilis, B.pumilus,M.luteus, E.coli and P.aeruginosa. Methanolic extract exhibited significant zone of inhibition and high biofilm percentage indicates potential antimicrobial agent. GC-MS report identified several bioactive palnt-derived compounds, which were carried for further studied to molecular docking against bacterial target protein. Among the identified compounds such as 5-(3-hydroxypropyl)-2,3- and D-allose displayed strong interactions with multiple bacterial proteins, in some cases approaching the binding energies of clinically used antibiotics,These investigation suggest that Syzygiumdiospyrifolium(Wall.ExDuthie) S.N.Mitra indicating positive outcome and innovative antimicrobial and antibiofilm agents. To the best of our review, this is the first documented on the medicinal value of these specific compounds from Syzygium diospyrifolium(Wall.ExDuthie) S.N.Mitra.