Development Of Nanoparticle-Embedded Transdermal Patches Of Losartan Potassium For Hypertension Therapy

Abstract

This research focuses on the formulation and characterization of nanoparticle-embedded transdermal patches of Losartan Potassium for effective hypertension therapy. The study aimed to enhance the bioavailability and controlled release of Losartan Potassium, an antihypertensive agent with limited oral bioavailability due to extensive first-pass metabolism. Nanoparticles were prepared using a suitable polymeric matrix, optimizing for size, drug entrapment efficiency, and stability. These nanoparticles were then incorporated into transdermal patches formulated with biocompatible polymers and evaluated for physicochemical properties, drug release kinetics, and mechanical strength. In vitro skin permeation studies using Franz diffusion cells demonstrated a sustained and enhanced release profile of Losartan Potassium compared to conventional formulations. Ex vivo and in vivo studies revealed improved drug permeation and significant antihypertensive effects, indicating greater therapeutic efficacy and patient compliance potential. The results suggest that nanoparticle-embedded transdermal patches provide a promising alternative for the management of hypertension by ensuring steady plasma levels, minimizing dosing frequency, and reducing systemic side effects associated with oral administration. This innovative delivery system could represent a significant advancement in hypertension treatment modalities, warranting further clinical investigation.