Study of Some Toxicological Properties of Sorbent from Plant Cellulose

Abstract

When studying the acute toxicity of a new agent based on plant cellulose, it was found that a single oral administrationprototyperats in doses of 2000; 4000; 6000 mg/kg of live weight did not have a negative effect on clinical and pathological parameters, animal survival, body weight gain and organ weight. The studied dosesexperimental sample of cellulose sorbentdo not cause death in rats, therefore, the average lethal dose has not been determined. The maximum dose administered was 6000 mg/kg. The facts revealed allow us to attributeexperimental sample of cellulose sorbentsubstances of hazard class 4 - low-hazard substances.

A single cutaneous application of a test sample of cellulose sorbent in doses of 1000 mg/kg, 2000 mg/kg and 3000 mg/kg also did not have a negative effect: it did not lead to the death of rats, and no signs of intoxication were noted.Cumulative properties of a new plant sorbent have been studiedThe data obtained from the research results indicate that the studied agent, when used for 28 days, does not exhibit a toxic effect on the body.Intragastric administration of the studied sorbent sample in increasing dosesdid not cause death of experimental ratsIn experimental rats that received the test sample, the morphological and biochemical parameters of the blood do not differ from those of control animals and reference values ​​characteristic of this species.According to the autopsy and macroscopic examination of the organs under study, no differences were found between the animals that received distilled water and the test agent. Analysis of the absolute weight of the internal organs of animals with subchronic administration of the plant sorbent did not reveal reliable differences between the groups of animals.