A Study on Plasma Fibrinogen Levels in Type 2 Diabetes Mellitus Patients and its Correlation With Microalbuminuria And Glycemic Control an a Tertiary Care Hospital in Eastern India

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a longterm metabolic condition, which is characterized by high morbidity and mortality, mainly on account of its vascular complications. Plasma fibrinogen is an acute-phase reactant and a major coagulation factor shown to play a significant role in microvascular and macrovascular complications of diabetes.

Objectives: The objectives of the study were (i) to quantify fibrinogen plasma in patients with T2DM, and (ii) to determine the relation between fibrinogen and glycated control and microalbuminuria.

Methods: The cross-sectional observational study was carried out in the Department of General Medicine, Burdwan Medical College and Hospital, West Bengal, at 18 months (March 20203 August 2021). A total number of 160 patients with confirmed T2DM who were aged between 30 to 70 years were involved. There was hyper-detailed demographic, clinical, and biochemical data. The parameters of fasting and postprandial BG, HbA1c, lipid profile, plasma fibrinogen (Modified Clauss Method), and urinary albumin-to-creatinine ratio were measured. Data analysis was done through SPSS v24.0 by using independent t-test, ANOVA, and Pearson correlation; a p-value < 0.05 was taken as significant.

Results: The average value of plasma fibrinogen was 394.7+/-86.5 mg/dl and a significant percentage of the patients exhibited hyperfibrinogenemia. The mean level of fibrinogen was significantly higher in patients with poor glycemic control (HbA1c > 8%) as compared to those with HbA1c 39; ltgr jet Gill wholesome 8 percent (p < 0.05). Likewise, macroalbuminuric patients had considerably high fibrinogen than normoalbuminuric patients.

Conclusion: Fibrinogen levels in plasma are increased due to T2DM, and correlate significantly with low glycemic control and microalbuminuria. Fibrinogen can help in establishing patients at the highest risk of complications regarding a vascular-related problem, including the integration of it in the regular management of diabetics.