Mechanism of PI3K-AKT Signaling Pathway Mediating Apoptosis of Periodontal Tissue Cells in Chronic Periodontitis

Abstract

Chronic periodontitis is one of the most common diseases in stomatology, which is characterized by the chronic inflammatory destruction of periodontal supporting tissues and is the most important cause of tooth loss in adults. The aim of this study is to explore the molecular mechanism of chronic periodontitis in Nanning, Guangxi, China, by using high-throughput sequencing technology combined with bioinformatics analysis. A case-control study was conducted. Periodontal tissue samples were collected from 30 healthy patients and 30 patients with chronic periodontitis in the Department of Stomatology, International Zhuang Medical Hospital Affiliated to Guangxi University of Traditional Chinese Medicine. KEGG enrichment and validation results showed that the PI3K-AKT signaling pathway was inhibited in the periodontal tissues of patients with chronic periodontitis in Nanning, Guangxi Zhuang Autonomous Region, which mediated the increase of Caspase9 expression and activated apoptosis, leading to apoptosis and destruction of periodontal tissues. These results suggest that PI3K-AKT signaling pathway may be a new target for clinical treatment of chronic periodontitis in Nanning, Guangxi Zhuang Autonomous Region.