Development and Characterization of Tablet Formulations containing Bioactive Compounds from Blatta orientalis

Abstract

The aim of this research was to develop and characterize tablet formulations containing bioactive compounds derived from Blatta orientalis, a medicinal insect (Cockroach) widely recognized in traditional systems for its therapeutic potential, particularly in respiratory and urinary tract conditions. The bioactive compounds previously extracted through optimized extraction techniques from the extract were then incorporated into tablet formulations using excipients that ensure stability, bioavailability, and patient compliance. Pre-formulation studies included the evaluation of flow properties, compressibility, and moisture content of the raw material. The tablets were characterized through a series of physicochemical evaluations, including disintegration time, hardness, dissolution profile, and friability to assess the performance and quality of the formulation. Additionally, stability studies were conducted under varying environmental conditions to ensure the shelf life.The results indicated that the optimized tablet formulation exhibited desirable physicochemical properties, stability, and a consistent release profile of the bioactive compounds, making it a promising candidate for further preclinical and clinical evaluation. This study provides a scientific basis for the standardization and development of Blatta orientalis-based therapeutic tablets, offering a potential novel treatment option in modern medicine.