Formulation, Development And Evaluation Of Econazole Nitrate Emulgel

Abstract

Objective: The aim of the present study was to develop a stable and effective emulgel formulation containing econazole nitrate for topical antifungal application.

Methods: UV–visible spectrophotometric analysis was performed. A stock solution was prepared by dissolving 10 mg of econazole in 10 ml of methanol to obtain a concentration of 1000 µg/ml. From this solution, 0.2 ml was withdrawn and diluted to 10 ml with methanol to obtain a 20 µg/ml solution, which was subjected to spectral analysis.

Results: Characterization of the drug sample indicated that econazole nitrate was white in colour, odourless, and crystalline in appearance. Solubility testing revealed solubility in methanol, ethanol (95%), and dimethyl sulfoxide (DMSO), while the drug was insoluble in water.

Conclusion: The development of econazole nitrate emulgel offers a promising therapeutic option for the management of superficial fungal infections, combining antifungal efficacy with a convenient and patient-friendly dosage form.