Correlation of MCP-1 And E-Selectin with Liver Inflammation In Chronic Hepatitis B
DOI:
https://doi.org/10.64252/cd5dgm93Keywords:
Hepatitis B Virus, MCP-1, E-selectin, Liver Inflammation, Biomarkers, Immune Response, Chronic Hepatitis, patients with hepatitis B (HB)Abstract
Hepatitis B Virus (HBV) infection is a major global health problem as it often progresses to chronic liver diseases both cirrhosis and hepatocellular carcinoma. The viral agent infection in the liver brings about complex interactions concerning inflammation where immune cells, cytokines, and adhesion molecules have critical roles in the evolution of the disease.
The work monitors pertinent applications of Monocyte Chemoattractant Protein-1 and E-selectin in HBV patients through serum levels evaluation and correlation analysis with clinical parameters. Raised levels of MCP- 1 (~0.1690 ± 0.0971 pg/mL) and E-selectin (~0.2569 ± 0.1051 pg/mL) in HBV patients, active hepatic inflammation.
A large positive correlation between MCP-1 and E-selectin (r = 0.467, p < 0.001) points to a concerted inflammatory reaction in monocyte recruitment and endothelial sticking. No significant correlations with these markers were demographic or renal function parameters, which underscores their specificity in regard to liver inflammation. From these results, it is implied that MCP-1 and E-selectin are useful as biomarkers for monitoring inflammatory activity in chronic HBV infection as well possible therapeutic targets.
