Evaluation Of Antidiabetic Potential Of Berberine On AlbinoWistar Rats

Abstract

Plant-derived secondary metabolites are small molecules or macromolecules biosynthesized in plants including steroids, alkaloids, phenolic, lignans, carbohydrates and glycosides, etc. that possess a diversity of biological properties beneficial to humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic and antioxidant activities Diabetes mellitus is a chronic disease result of metabolic disorders in pancreas β-cells that have hyperglycemia. Hyperglycemia can be caused by a deficiency of insulin production by pancreatic (Type 1 diabetes mellitus) or insufficiency of insulin production in the face of insulin resistance (Type 2 diabetes mellitus).  Chemical compounds derived from plants have been used since the origin of human beings to counteract a number of diseases. The alkaloid has drawn extensive attention as therapeutics against a number of diseases including hyperlipidemia, metabolic syndrome and polycystic ovary syndrome. In present study an attempt has been made to evaluate the antidiabetic activity of berberine in different doses.