Integrative Assessment Of Motor Activity And Catalepsy In Albino Rats: Roles Of Citral, Zonisamide, And Monoamine Modulators

Abstract

Catalepsy is a neurological finding of prolonged muscular rigidity and immobility, where the individual’s limbs remain in an unnatural, fixed posture. The condition results in decreased response to external stimuli and reduced sensitivity to pain. Catalepsy involves a loss of voluntary motion, muscle rigidity, fixed posture, and decreased sensitivity to pain. It is a symptom of a number of conditions including epilepsy, Parkinson's disease, substance use, catatonia, schizophrenia, and as a side effect of some types of medication used to treat schizophrenia. It is a state of immobility and is thought to be associated with the blockade of dopaminergic pathways in the basal ganglia. Monoamine modulators are substances that alter the activity of monoamine neurotransmitters in the brain. These neurotransmitters, including dopamine, serotonin, and norepinephrine, play crucial roles in regulating mood, cognition, and various other brain functions. Monoamine modulators can either enhance or inhibit the effects of these neurotransmitters, leading to changes in neuronal signaling and ultimately affecting behavior and mental state. Catalepsy can be measured by the means of the bar test in experimental animals. In present study an attempt was made to study the Effect of Haloperidol, Zonisamide, Citral, Serotonin analogue antagonist/antagonist, Dopamine analogue antagonist/antagonist on haloperidol induced cataleptic effect in Bar Test