Assessment Of IL-22 Receptor As A Diagnostic Biomarker For Recurrent Utis
DOI:
https://doi.org/10.64252/bgsj3z63Keywords:
IL-22R , recurrent ,UTI, E.coli , Klebsiella pneumonia, urine.Abstract
Background: The surface of epithelial cells expresses IL-22R in
mucosal tissues such as the urinary tract, and its elevated levels in urine indicate an inflammatory response. This receptor is part of the cytokine family and interacts with IL-22.
Objective :Assessment of IL-22R levels in urine from individuals who have recurrent UTIs.
Methods:This study included only 68 urine samples from individuals aged 6 to 60 years and older, males and females suffering from recurrent urinary tract infections from Imam Al-Sadiq Hospital (AS) in Babylon Governorate, Iraq, during the period enzyme-linked immunosorbent assay (ELISA), which is an indicator of urinary tract infection. We also compared it with 30 control samples.
Results :The mean level of IL-22R in urine samples of patients was 1562 ng/l, while that of the control group was 1076 ng/l, with statistically significant differences (P=0.003), It indicates a statistically significant variation inIL-22R levels between patients and the healthy control group. Since P is less than 0.05, the difference is significant andstatistically significant at the 0.05 threshold of significance. Also, the level of this interleukin in urine samples of males was 1401 ng/l and in urine samples of females was 1548 ng/l, with a value of (P=0.484), which means that there is no statistically significant difference between males and females in IL-22R levels in urine. This indicates that gender does not clearly affect the concentration of this biomarker in urine.
Conclusion: IL-22R levels are elevated in cases of urinary tract infections, and this study found that testing for IL-22R protein in urine can be used as a biomarker for diagnosing urinary tract infections.
