Formulation And Characterization Of Nanofibers Incorporating Pravastatin For Potential Anti-Inflammatory Activity.

Abstract

The current study investigates the formulation and characterisation of nanofibersformulation (POAF2) containing Pravastatin, Aloe vera juice, and onion oil for prospective anti-inflammatory applications. The organoleptic properties, solubility, UV, FTIR, and DSC analyses confirmed the compatibility of the drug and excipients, with no significant interactions observed. Phytochemical analysis identified bioactive substances in Aloe vera and onion oil, demonstrating their medicinal potential. Optimized nanofibre formulations demonstrated higher drug content (96.09%), entrapment efficiency was 94.84%, and extended drug release. Stability experiments conducted over a three-month period demonstrated no fluctuations in the drug's characteristics. The in vivo anti-inflammatory trial revealed a notable improvement with nanofibretherapy (40.60%) within 3 hr relative to the control group. Histopathological assessment revealed normal skin architecture with slight epithelial alterations in treated samples, further substantiating the promising therapeutic potential of these nanofibre compositions for anti-inflammation.