Synthesis And Characterization Of Some Novel Indole Carboxamide Derivative And Its Anti-Inflammatory & Analgesic Evaluation

Abstract

An indole carboxamide derivative is a structure that has an indole ring system, which is made up of a benzene ring and a pyrrole ring, with a carboxamide group (-CONH₂ or a variation of it) attached to one of the ring positions, usually at the 3-position (3-carboxamides) or 2-position (2-carboxamides) derivatives of indole-carbohydrazides indole-2-carbohydrazides (1a-b) and carboxaldehydes (2a-d) was reacted to produce indole carbohydrazide derivatives (4a-h) and indole carboxamide derivatives (5a-h), respectively. Formaldehyde was then added to the mixture. Using spectral data, the structures of every freshly synthesized molecule were verified. These substances have all undergone screening for analgesic and anti-inflammatory properties. The percentage inhibition of for anti-inflammatory potential was 73.02% and for analgesic activity resulted in a pain alleviation rate of 63.18% after a period of sixty minutes of use.